PUBLICATIONS
Discovery of novel, potent and orally available benzoazipinone derivatives that elicit MKLP2-inhibitory phenotypes
Research Article – European Journal of Medicinal Chemistry Reports
2024
2024
MYC amplifies mitotic perturbations elicited by LXY18 to enable synthetic lethality
Research Article – bioRxiv
2023
2023
Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound
Research Article – Journal of Pharmacy and Pharmacology Research 7
2023
2023
The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells
Research Article – PLOS ONE
2023
2023
Orally bioavailable 4-phenoxy-quinoline compound as a potent Aurora Kinase B relocation blocker for cancer treatment
Research Article – ACS Pharmacology & Translational Science
2023
2023
In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis
Research Article – Journal of Pharmaceutical and Biomedical Analysis
2023
2023
An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment
Research Article – BioRxiv
2023
2023
Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B
Research Article – Bioorganic & Medicinal Chemistry
2023
2023
2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization
Research Article – European Journal of Medicinal Chemistry
2022
2022
The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells
Research Article – International Journal of Molecular Sciences
2022
2022
Discovery and Optimization of Seven-Membered Lactam-Based Compounds to Phenocopy the Inhibition of the Aurora Kinase B
Research Article – ACS Medicinal Chemistry Letters
2022
2022
Powerful Molecule Generation with Simple ConvNet
Research Article – Bioinformatics
2023
2023
The Phytochemical, Corynoline, Diminishes Aurora Kinase B Activity to Induce Mitotic Defect and Polyploidy
Research Article – Biomedicine & Pharmacotherapy
2022
2022
The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects
Research Article – Journal of Natural Products
2021
2021
Mini-library approach delivers an arsenal in drug development pipeline
Article – Drug Discovery World
2021
2021
A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil
Research Article – PLOS One
2021
2021
A high-content screen for anti-mitosis and polyploidy-induction identifies an unknown activity of two benzophenanthridine alkaloids from Corydalis longicalcarata
Research Article – Phytochemistry Letters
2021
2021
Emerging Strategies to Attack Polyploid Cancer Cells
Review Article – Journal of Cellular Immunology
2020
2020
Pro-survival Bcl-2 proteins are modifiers of MYC-VX-680 synthetic lethality
mmentary – Journal of Cellular Immunology
2020
2020
The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells
Research Article – Experimental Cell Research
2020
2020